extra virgin olive oil in maternal diet in, but high amount has deleterious effects creases osteogenic genes expression on bones in mice offspring at adolescence

نویسندگان

seyedeh neda mousavi department of cellular molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran

department of biochemistry and nutrition, school of medicine, zanjan university of medical sciences, zanjan, iran

fariba koohdani department of cellular molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran

mohamadreza baghaban eslaminejad department of stem cells and developmental biology, cell science research center, royan institute for stem cell biology and technology, acecr, tehran, iran

چکیده

objective(s): maternal high-fat diet has been shown to have deleterious effects on the offspring bones. however, there is no study to assess the effects of type and amount of maternal dietary oil in an isocaloric diet, with focus on extra virgin olive oil (evoo). the objective of the current study was to test the hypothesis that type of maternal dietary oil has more effects than its amount in an isocaloric diet during gestation and lactation on bone genes expression in offspring in adolescence. materials and methods: virgin female c57bl/6 mice were impregnated and fed either the ain 93g diet (received 16% of calories as soybean oil, as a control diet, or evoo) or a high fat ain 93g diet (received 45% of calories as soybean oil or evoo) from the time of vaginal plug confirmation until offspring’s weaning. results: after adjusting for the amount of oils, osteoprotegerin/ receptor activator of nuclear factor nf-κb ligand (opg/rank-l) and opg expressions were 6.1- and 2.8-folds higher in offspring born to evoo compared with soybean oil-fed mothers. opg, beta-catenin, and opg/rank-l expression were 88%, 94%, and 70% lower in offspring born to the 45% oil-fed mothers compared with the 16% group. in contrast, peroxisome proliferator-activated receptor gamma-2 (pparγ2) gene expression was higher in the 45% oil group, adjusted for the types of oil. conclusion: maternal evoo consumption, but not soybean oil increased osteoblastic gene expression, and high amounts of both oils decreased osteoblastic and increased adipogenic genes expression in adolescent offspring.

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منابع مشابه

Extra virgin olive oil in maternal diet increases osteogenic genes expression, but high amounts have deleterious effects on bones in mice offspring at adolescence

Objective(s): Maternal high-fat diet has been shown to have deleterious effects on the offspring bones. However, there is no study to assess the effects of type and amount of maternal dietary oil in an isocaloric diet, with focus on extra virgin olive oil (EVOO). The objective of the current study was to test the hypothesis that type of maternal dietary oil has more effects than its amount in a...

متن کامل

extra virgin olive oil in maternal diet increases osteogenic genes expression, but high amounts have deleterious effects on bones in mice offspring at adolescence

objective(s): maternal high-fat diet has been shown to have deleterious effects on the offspring bones. however, there is no study to assess the effects of type and amount of maternal dietary oil in an isocaloric diet, with focus on extra virgin olive oil (evoo). the objective of the current study was to test the hypothesis that type of maternal dietary oil has more effects than its amount in a...

متن کامل

Extra virgin olive oil in maternal diet increases osteogenic genes expression, but high amounts have deleterious effects on bones in mice offspring at adolescence

OBJECTIVES Maternal high-fat diet has been shown to have deleterious effects on the offspring bones. However, there is no study to assess the effects of type and amount of maternal dietary oil in an isocaloric diet, with focus on extra virgin olive oil (EVOO). The objective of the current study was to test the hypothesis that type of maternal dietary oil has more effects than its amount in an i...

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Effects of Maternal Isocaloric Diet Containing Different Amounts of Soy Oil and Extra Virgin Olive Oil on Weight, Serum Glucose, and Lipid Profile of Female Mice Offspring

Background: Health status of offspring is programmed by maternal diet throughout gestation and lactation. The present study investigates the lasting effects of maternal supplementation with different amounts of soy oil or extra virgin olive oil (EVOO) on weight and biochemical parameters during gestation and lactation of female mice offspring.Methods: Eight weeks old female C57BL/6 mice (n=40) ...

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An extra-virgin olive oil rich in polyphenolic compounds has antioxidant effects in OF1 mice.

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Effects of Maternal Isocaloric Diet Containing Different Amounts of Soy Oil and Extra Virgin Olive Oil on Weight, Serum Glucose, and Lipid Profile of Female Mice Offspring

BACKGROUND Health status of offspring is programmed by maternal diet throughout gestation and lactation. The present study investigates the lasting effects of maternal supplementation with different amounts of soy oil or extra virgin olive oil (EVOO) on weight and biochemical parameters during gestation and lactation of female mice offspring. METHODS Eight weeks old female C57BL/6 mice (n=40)...

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۹، شماره ۱۲، صفحات ۱۲۹۹-۱۳۰۷

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